Right, there has to be...compression loss contributes to digital generation loss (one short cut is passed on to another, which can create another short cut). And although 'lossless' is used as a code word (har) it's still compression, which means it will contain artifacts. Maybe not perceivable by 99% of the population, but hey, if a company can use 'Miracle Whip' for rotten eggs then why not Lossless Audio for 1's and 0's.
I wonder how many transcodings from one format to another and back again can cause enough loss it approaches a static, and maybe unrecognizable data?